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Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), both increasing in incidence, have become a major topic of basic and clinical research as well as clinical practice in hepatology. Experts in the field update the current concepts on the carcinogenesis of HCC and CC such as genetic alterations in the pathways of cell cycle and apoptosis regulation, the hypothesis of dedifferentiation of hepatocytes to the malignant phenotype vs that of activation of hepatic progenitor cells incapable of maturation (maturation arrest hypothesis). In spite of an increasing number of genetic alterations described in human HCC as well as cell regulatory pathways tested in experimental HCC models, the key hits causing progression of the cell cycle in imbalance with apoptosis, tissue invasive growth and metastatic potential of cell clones still remain elusive. Very powerful genomic and proteomic techniques are promising insights into the carcinogenesis of liver malignancies that will allow more efficient therapeutic strategies. The current concepts on risk profiling, surveillance of risk groups and therapeutic strategies are evidence-based for HCC and less detailed for CC. Surveillance of risk groups improves detection of liver tumours in curable stages. Best strategies for curative treatment of HCC use neoadjuvant antitumour therapies before liver transplantation and a role is emerging for living donor-related liver transplantation. New palliative therapies for HCC are in the experimental stage with biological response modifiers, including angiogenesis inhibitors, and entering phase II clinical trials with the alpha-fetoprotein derived vaccines.211pp.N.B.Slight fade mark to base of d/j spine.
Kluwer Academic Publishers, 2002, Cloth, Book Condition: Like New, Jacket Condition: Like New. . . 8vo - over 7" - 9" tall.
ISBN: 0792387791
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Inventory #14692
Price: £ 40.00 GBP ($ 48.00 approx. - € 42.40 approx.)
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Frisch, B.; Bartl, R.
216pp.Top of D/J spine slightly creased.
Kluwer Academic Publishers, 1990, Cloth, Book Condition: Like New, Jacket Condition: Very Good. . . 4to - over 9" - 12" tall.
ISBN: 0792389212
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Inventory #14869
Price: £ 25.00 GBP ($ 30.00 approx. - € 26.50 approx.)
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Conzelman, Adrienne Ruger
After the hunt is an in depth catalogue of the most intriguing examples in the William B. Ruger collection of over 200 works of art. 197pp.Features the art collection of William B Ruger, the famed arms-maker, who passed away in June 2002. Christie's conducted a multi-million dollar auction in December 2002 of the paintings that appear in the book. The book includes approximately 20 paintings sold by Christies, NY and includes 83 colour photos of William B Ruger's private collection. The pieces depict the American West, hunting, wildlife, historical and classic art, and seascapes by artists such as Frederic S Remington, Maxfield Parrish, Albert Bierstadt, Arthur Fitzwilliam Tait and many others. Seth Eastman's 'Winnebago Encampment', Alexander Phimister Proctor's 'The Indian Warrior', and Frank Tenney Johnson's 'Cowboy on Horseback' are examples.
Stackpole Books, 2002, Cloth, Book Condition: Like New, Jacket Condition: Like New. First Edition. Heavy Item Postage Quote. Folio - over 12" - 15" tall.
ISBN: 0811700372
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Inventory #6012
Price: £ 30.00 GBP ($ 36.00 approx. - € 31.80 approx.)
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Hunt,Richard H. And Tytgat,Guido N.J.
The fourth meeting in the series "Helicobacter pylori: Basic Mechanisms to Clinical Cure" was held on the island of Bermuda in late March 2000 and was sponsored by Axcan Pharmaceuticals. This was only some two years after the third meeting in San Diego, and it seemed hardly possible that there would be so much new information. However, as the contributions in this volume testify, there was plenty of new information with important implications for both understanding this infection and for clinical management. Some of this information was of a fundamental nature, such as the role of the acid sensitive urei channel in regulating the influx of urea and the formation of transported ammonia back in the microbial perisplasmic space to neutralize acid; the observation of genetic polymorphism of the IL-1b gene as an explanation of achlorhydria and gastric cancer risk in the first-degree relatives of gastric cancer patients; and the peculiar biochemical and physiological consequences of the genome of the microorganisms. The format of the meeting, with fifteen-minute presentations by world experts closely involved in helicobacter research followed by ample time for panel discussions, was again followed this year. Traditional aspects included detailed study of the microbial characteristics, the novel helicobacters, the interaction with the human host, the peculiarities of the inflammatory immune response, the short and long-term mucosal consequences, the effects on acid secretion, the problem of gastric malignancy, and the therapeutic possibilities. However, a series of short debates was introduced to highlight controversial issues, such as the pathogenic or commensal role of the organism, the role of virulence factors, the characteristics of the inflammatory immune response, the reversibility of mucosal atrophy and metaplasia, and the primary or secondary role of quadruple therapy, to name just a few. This provocative approach was very successful and provided fuel for further in-depth discussions. These debates have been included in this book in the form of conventional manuscripts in order to maintain the shortest possible production time for the publication of the proceed Helicobacter pylori has come a long way since the first meeting in Amelia Island, in 1993, and the science of this organism and the understanding of the consequences of the infection have advanced our knowledge fundamentally and revolutionized our thinking about gastrointestinal disease. We now recognize the existence of more than thirty Helicobacter species, some of which may play a significant role in human disease. The experience gained through our investigation of H. pylori promises to make a significant contribution to the future exploration of the possible role of Helicobacter species in hepatic, biliary, and intestinal diseases. 689pp.N.B.Slight annotation to first few pages.
Kluwer Academic Publishers, 2000, Cloth/Laminated Boards, Book Condition: Very Good, Jacket Condition: No d/j as Published. . . 8vo - over 7" - 9" tall.
ISBN: 0792387643
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Inventory #14961
Price: £ 20.00 GBP ($ 24.00 approx. - € 21.20 approx.)
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Malvee, Sangeeta
Biotechnology is a technique that uses living organisms to create and amend a product, to develop plants and animals or to develop micro-organisms for explicit uses. Biotechnological means of genetic improvement is a modern and faster approach. Genome manipulations (Chromosomal Engineering) and gene transfer (Genetic Engineering) have been experimentally studied throughout past in many countries. To date genetic progress in livestock breeding programs has relied whichever on breed exchange or leading the conventional quantitative genetic approach of testing and selection.Under these circumstances the need to develop new technologies became imperative unlike in agriculture and veterinary farming exploitation of genetic potentials and utilization of genetically improved cultured varieties of fish is not a common practice in aquaculture all most all species of fish are genetically improved to the traditional selective reading and hybridization methods. Aquaculture is multidisciplinary activity. This book overviews Fishes and related biotechnology techniques. Reading this book will be beneficial for students of fisheries, researchers in this field and entrepreneurs. 471pp. N.B. Edges and corners bumped. Head and tail of spine bumped.
SBS Publishers, 2008, Cloth/Laminated Boards, Book Condition: Very Good, Jacket Condition: Very Good. . . 8vo - over 7" - 9" tall.
ISBN: 9788189741631
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Inventory #24931
Price: £ 20.00 GBP ($ 24.00 approx. - € 21.20 approx.)
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