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The Humanities Bookstore offers for sale second-hand, new, academic and antiquarian books on the Humanities and Social Sciences and other subjects.
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Edited By Waring,M.J. And Ponder,B.A.J.
Most of the anti-cancer drugs in use today were discovered by happy accident rather than design, yet the rational design of better anti-cancer drugs remains a cherished goal, and one of the most important challenges facing medical science. This work represents a compilation of views and progress reports which illustrate the diversity of approaches to the problem. Recent research has confirmed the belief that critical genetic changes are at work in cancer cells. The genome (DNA in biochemical terms) represents a critical target for specific chemotherapy of cancer, and several chapters address the issue of attacking DNA, gene targetting, and the like. Others deal with principles of rational design, exploitation of novel modalities and targets, or the nuts and bolts of antitumour drug testing. While no attempt has been made to provide a comprehensive coverage of this wide-ranging subject, this volume aims to provide much food for thought.284pp.
Kluwer Academic Publishers, 1992, Cloth, Book Condition: Like New, Jacket Condition: No d/j as Published. . . 8vo - over 7" - 9" tall.
ISBN: 079238959X
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Inventory #15607
Price: £ 25.00 GBP ($ 32.58 approx. - € 27.63 approx.)
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Edited By Berg,P.A.
Ursodeoxycholic acid (UDCA) has been shown by many studies to be of benefit in the treatment of primary biliary cirrhosis (PBC) and also of primary sclerosing cholangitis (PSC) (and other cholestatic liver diseases), but the mechanism of action of this drug remains obscure and is, in all probability, of multifactorial nature. Possibly, complex interaction of immunomodulatory and membrane-stabilizing effects in conjunction with an altered composition of the bile acid pool are responsible for the beneficial effect. This book, the proceedings of 86th Falk Symposium "Bile Acids and Immunology" (Part 1 of the Basel Liver Week), held in Basel, Switzerland, October 17-18, 1995, starts with an update on important mechanisms involved in autoimmune mediated processes covering the presentation of antigens and autoantigens by professional and non-professional antigen presenting cells, the recognition of the MHC-antigen complex by T-cells, the role of natural and disease-specific antibodies, as well as the control of immune processes via TH1/TH2 cells and their cytokines. It then focuses on the recent findings concerning the aetiopathogenesis of PBC and PSC and the effect of UDCA therapy in these disorders. The most relevant questions which have to be answered in this field are: is the biochemical improvement the consequence of a true antiinflammatory or immunosuppressive effect of UDCA or only due to the replacement of hydrophobic by hydrophilic bile acids?; does UDCA increase the efficacy of immunosuppressive drugs and is it necessary to differentiate between patients who need either a mono-UDCA or a combined (UDCA/steroids) therapy?; are PBC and PSC true autoimmune disorders driven by an autoantigen or only "secondary autoimmune" processes induced by a persisting infectious agent, considering the poor response of both disorders to immunosuppressive treatment as compared to patients with autoimmune hepatitis? This book tries to clarify these problems and open new avenues for further research. It should be of interest to all clinicians and researchers in the field of bile acids. N.B.D/J spine slightly faded with slight mark to base of d/j spine.295pp.
Kluwer Academic Publishers, 1996, Cloth, Book Condition: Like New, Jacket Condition: Very Good. . . 8vo - over 7" - 9" tall.
ISBN: 0792387007
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Inventory #15664
Price: £ 20.00 GBP ($ 26.06 approx. - € 22.10 approx.)
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Halper, June (editor); Holland, Nancy J. (editor)
Multiple sclerosis (MS) is a chronic, frequently debilitating neurologic disease that is most often diagnosed at a relatively young age. The disease lasts a lifetime, and involves a wide range of issues, some disease-related and others the result of living and aging with a chronic and sometimes disabling condition. This superb volume is the only definitive text on the comprehensive nursing care of people with MS. As the most direct link to patients and their families, nurses are in the unique position of providing a conduit for physicians and other health care professionals to work with patients, their families, and the community. Nursing care in MS is a collaboration between the patient/family and the nurse, a partnership whose goal is self-awareness and self-responsibility; whose activities involve a great deal of self-care. This book is not simply a nursing text - the lessons that it imparts will be useful in many fields of chronic disease management. The book opens with an overview of multiple sclerosis and its implications for nursing practice; a discussion of theoretical concepts, research, and clinical trials; and an overview of symptom management. This is followed by chapters dealing with specific areas relating to nursing management of the person with MS, including the management of elimination dysfunction, the prevention of complications in severely disabled individuals, psychosocial issues, sexuality and family planning, issues of special relevance to female patients, and interactions with rehabilitation services. Of particular interest are chapters dealing with the nursing implications of disease modifying agents, the role of complementary therapies, patient and family education, client advocacy, and hope as a unifying concept in managing this unpredictable disease. Appendices that include an extensive list of resources and medication sheets for all of the most commonly used agents in the management of multiple sclerosis will be referred to constantly.
Demos Medical Publishing, Incorporated, 2002, Paperback, Book Condition: Like New, Jacket Condition: No d/j as Published. Second Edition. . 8vo - over 7" - 9" tall.
ISBN: 1888799641
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Inventory #6696
Price: £ 5.00 GBP ($ 6.52 approx. - € 5.53 approx.)
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Bryan, Lowell L.; Joyce, Claudia L.

McGraw-Hill, 2007, Cloth, Book Condition: Like New, Jacket Condition: Like New. . . 8vo - over 7" - 9" tall.
ISBN: 9780071490825
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Inventory #29613
Price: £ 7.50 GBP ($ 9.77 approx. - € 8.29 approx.)
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Flax, Jane
"Disputed Subjects" analyzes the assumptions behind contemporary notions of justice and knowledge and discusses why modernity cannot be emancipatory. The text explores the effects of gender relations in modern political ideas and theories of knowledge. The author identifies problematic aspects of discourses such as psychoanalysis, postmodernism and feminist theory. Special attention is paid to recurring difficulties with maternity, sexuality and race within feminist theory, and the inadequacies of postmodern accounts of subjectivity and gender. The book analyzes psychoanalysis to identify its particular organization of knowledge and power. Previous owner's signature on ffep.188pp.
Routledge, 1993, Paperback, Book Condition: Fine, Jacket Condition: No d/j as Published. . . 8vo - over 7" - 9" tall.
ISBN: 041590790X
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Inventory #24751
Price: £ 7.50 GBP ($ 9.77 approx. - € 8.29 approx.)
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